This, coupled with insufficient shedding of exfoliating dead skin cells, plugs hair follicles. The plugged follicle can become inflamed and have increased growth of the normal skin bacteria Propionibacterium acnes. Medications such as lithium, cortisone, hormones, some seizure medications, or some antibiotics can also cause acne lesions.
There is no cure for acne, but certain measures can help prevent breakouts. Acne can result in scarring, so minimizing breakouts is worthwhile.
Acne affects 85–100% of people at some point in their lives, and usually begins at puberty. Acne can persist into the 30s and beyond. In fact, 5% of people over 45 still have acne.
Acne results in a variety of lesions. The most common acne locations include the face, neck, chest, and back, where the most sebaceous glands are located. Along the jaw line is a common location in adults. "Blackheads" (open comedones) and "whiteheads" (closed comedones) are follicular plugs that are either sitting below the skin surface (whitehead) or oxidized from being exposed to the air (blackhead). Papules are small pink to reddish-brown bumps, pustules are pus-filled lesions, and nodules or cysts are deeper pus-filled lesions.
Mild acne consists of a few papules/pustules and/or comedones. Moderate acne has an increased number of lesions. Severe acne has numerous comedones, papules, pustules, and may have painful nodules.
Acne can result in permanent scars, which can appear to be depressions in the skin or hyperpigmentation, which is dark red or brown flat marks where the acne lesions were.
Traditional treatments can help prevent acne. Cleanse the acne-prone areas with gentle soaps or cleansers. Avoid irritants, such as rubbing and other alcohols, and abrasive scrubs and greasy products on the skin and in the scalp. Products labeled "water-based" or "noncomedogenic" will help reduce clogged pores.
There are also a variety of over-the-counter medications that can help. These are preventative therapies and work best when regularly applied in a thin layer to the affected area. If applied consistently, you may see small improvements quickly, but results are generally seen after a few months. Benzoyl peroxide (most effective), is available in a variety of forms and strengths. This tends to dry skin, so use a weaker-concentration product if you have dry skin, and higher strength for oily skin. Be careful getting it on clothing and towels as it can bleach fabric. Peeling agents (exfoliants) such as salicylic acid, sulfur, resorcinol, and alpha-hydroxy acids (glycolic, lactic, pyruvic, and citric acid) can also help but will also cause some dryness of the skin.
Microdermabrasion performed every 7–10 days (the "lunchtime peel") has been a popular way to control mild acne and can be done by a health care professional. The same types of peeling agents are available in over-the-counter products, which can be used at home at much less cost.
Oral treatments may include:
Antibiotics: tetracycline, minocycline, doxycycline, erythromycin, ampicillin, clindamycin, trimethoprim-sulfamethoxazole, azithromycin, or cephalosporins.
Oral contraceptives and spironolactone have been found to help regulate hormones.
Isotretinoin: a powerful drug with potential side effects, for severe acne unresponsive to the above treatments, or with acne that causes scarring.
Special "blue light" LED treatments such as Omnilux have shown good results in some cases. Several types of laser treatments also help acne and are often used with other treatment methods; treatments are expensive, must be repeated for several months, and have variable efficacy. Insurance may not cover laser therapy.
Laser resurfacing, plastic surgery, and/or dermabrasion may help reduce the prominence of old acne scars.